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Vaccine development

CD8 T cell priming occurs in two phases. In the activation phase (day 1), naïve T cells engage with dendritic cells (DC) for 24 hours, then detach, proliferate, and move deeper into the lymph node. In the selection phase (days 2-3), activated T cells regain sensitivity, re-engage with antigen-presenting cells, and receive IL-2 support from CD4 T cells. Regulatory T cells limit IL-2 availability, driving the expansion and differentiation of high-affinity CD8 T cells into effector cells.

Hidden Dance of T-Cells Reveals New Immune System Strategy Against Viruses

Categories Health

Photos of monkeypox in British patients, May 2022

New mRNA Vaccine Outperforms Current Options in Mpox Battle

Categories Health

The first PrEPVacc volunteer participant receives an injection at the launch of the launch of the PrePVacc Trial at the Masaka site of the MRC/UVRI and LSHTM Uganda Research Unit, on Tuesday 15 December 2020.

HIV Vaccine Trial Fails to Prevent Infections, Raises New Questions

Categories Health

Jonah Sacha, Ph.D., senior co-author of a study published today in the journal Nature Communications, says the research could lead to a universal influenza vaccine within five years.

Universal Flu Vaccine Shows Promise

Categories Health, Technology

Transmission electron micrograph of HIV-1 virus particles (blue) from infected H9 cells, produced in cell culture. The particles exhibit two stages of replication: the two “arcs” are immature particles budding from the plasma membrane of the cell, and the center spherical particle is a mature form in extracellular space. Image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland.

Engineered Nanoparticles Stimulate Rare Antibodies Against HIV in Animals, Advancing Vaccine Development

Categories Health

Battle against fatal neurodegenerative disease advances on two fronts

Categories Bloggers

Kim D. Janda, PhD, the Ely R. Callaway, Jr. Professor of Chemistry at Scripps Research. Credit: Scripps Research

Scientists Develop Vaccine to Combat “Zombie Drug” Xylazine Overdose

Categories Health

Nurse delivers covid vaccine to woman patient's arm

Researchers develop more broadly protective coronavirus vaccine

Categories Health

Researcher in a fancy lab looking through a microscope

Priming, shaping and polishing: In search of a HIV vaccine

Categories Health, Technology

Trivalent vaccine candidate fights measles, mumps, SARS-CoV-2

Categories Technology

Transmission electron micrograph of HIV-1 virus particles from infected H9 cells, produced in cell culture. The particles exhibit two stages of replication: the two “arcs” are immature particles budding from the plasma membrane of the cell, and the center spherical particle is a mature form in extracellular space. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland.

Clinical trial of HIV vaccine begins in United States and South Africa

Categories Health

A colorized transmission electron micrograph of influenza A virus particles, colorized orange, isolated from a patient sample and then propagated in cell culture. NIAID

NIH clinical trial of universal flu vaccine candidate begins

Categories Health

Digging deeper into how vaccines work against parasitic disease

Categories Technology

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